Most of the patients with gallbladder wall thickening do not have obvious symptoms. Gallbladder wall thickening is commonly caused by gallbladder diseases, liver diseases, cardiac insufficiency and hypoproteinemia. 1. Gallbladder diseases: such as cholecystitis or gallbladder cancer, etc., this kind of disease is mostly in the gallbladder stones on the basis of lesions, gallbladder stones repeatedly stimulate the gallbladder wall will lead to gallbladder wall roughness thickening. 2. Liver diseases, such as hepatitis and cirrhosis, are caused by long-term congestion and necrosis of liver cells, resulting in sufficient inflammatory cell infiltration of the mucosa of the gallbladder wall, resulting in gross thickening of the gallbladder wall. 3. Cardiac insufficiency and hypoproteinemia: right heart failure and hypoproteinemia can lead to gallbladder wall edema and thickening. Hirsutism of the gallbladder wall can also be seen in other diseases, when such symptoms appear, it is recommended to consult a doctor in time.