Raised red spots on the surface of the skin, which are not painful or itchy, may be related to micro hemangioma, syphilis and other diseases. 1. Small hemangioma: it is a benign tumor caused by congenital abnormalities of blood vessel development, which will not affect the body except for aesthetics and will not cause obvious pain and itching discomfort. 2. Syphilis: it is a disease caused by the infection of syphilis spirochete with sexual contact as the main way of transmission. Due to the lack of standardized treatment, syphilis will appear in syphilis rash when it enters into the second stage, which can be manifested as a red, pink rash or maculopapular rash appearing all over the body, and even in the palms of the hands and soles of the feet, which can be painless and itchy. There may be other reasons for the prominent red spots on the skin that are painless and itchy, so it is recommended that the patient go to the hospital, clarify the cause of the disease, and follow the doctor’s instructions for treatment.