Early stage of liver cancer can be manifested as hypodense shadow of liver. Early hepatocellular carcinoma is mostly manifested as hypodense foci on CT examination, and “fast-in-fast-out” manifestation can be seen on multi-phase enhanced CT scan (i.e. tumor foci in arterial phase are obviously intensified; tumor foci in venous phase are relatively hypodense, with enhancement of normal hepatic parenchyma; and tumor density in equilibrium phase continues to be reduced, with obvious contrast with the normal tissues in the surroundings). Generally, patients are found to have lesions with the above features, and the diagnosis of hepatocellular carcinoma can be clarified by combining with other examinations such as alpha-fetoprotein test or pathology/histological examination. Meanwhile, MRI is also of high value in the diagnosis of early hepatocellular carcinoma: when cirrhosis is present, low and high signals on T1WI and low signals on T2WI, once high signals appear in the low signal lesions on T2WI and “fast in, fast out” performance on multiple enhancement scans, it suggests that it is an early stage of hepatocellular carcinoma. If liver cancer is suspected or diagnosed, it is recommended to go to regular hospitals to evaluate the condition and follow the doctor’s instructions for treatment.