The common causes of pain in the middle of the rib cage include fracture, intercostal neuritis, tumor and so on. 1. Fracture: Fracture or invisible fracture of ribs will cause pain in the middle of ribs, the pain may not be intense, and it is hidden pain. 2. Intercostal neuritis: aseptic inflammation of intercostal nerves is often manifested as pain in the area innervated by intercostal nerves, and the pain is often pinprick-like, burning-like, and band-like distribution. 3. Tumor: primary tumor or metastatic tumor in the rib cage or chest wall may also cause intercostal pain. The pain in the middle of ribs may also be caused by other reasons, which should go to the hospital in time to find out the causes and carry out targeted treatment.