Focal segmental glomerulosclerosis is usually incurable and has a poor prognosis. Spontaneous remission is possible in only a very small number of patients.
Focal segmental glomerulosclerosis is a common primary glomerular disease in children and adults with nephrotic syndrome, the main cause of which is segmental scarring of the glomeruli, which is usually irreversible damage and incurable, but it can be treated with medication to achieve symptomatic relief and delay the progression of the disease.
Focal segmental glomerulosclerosis generally has a relatively poor overall prognosis, with about half of patients developing end-stage renal disease within 10 years.
Factors associated with prognosis include the degree of proteinuria, renal function at the time of onset, chronic lesions in the pathology, whether or not the nephrotic syndrome is in remission, and the type of pathology; patients with the tip-type generally have a better long-term prognosis than the other types, whereas the cellular and collapsed types have the worst prognosis. Less than 5% of primary focal segmental glomerulosclerosis resolves spontaneously.
Focal segmental glomerulosclerosis treatment has a poor prognosis, and it is recommended that patients seek medical treatment in regular hospitals in time and standardize the treatment under the guidance of physicians.