Patients with negative tetanus test sensitivity can be directly injected with tetanus antitoxin; however, for patients with positive test sensitivity, tetanus antitoxin cannot be injected, and tetanus immunoglobulin can be injected instead; desensitization for tetanus antitoxin injection can be considered for patients with allergy. Tetanus injection tetanus toxin before the need to carry out a strict test sensitivity, to avoid patients with allergic reactions, life-threatening. For patients who are not allergic to tetanus is injected tetanus toxin belongs to a kind of passive immunity, neutralize tetanus spasmodic toxin, can effectively improve the symptoms, but tetanus immune globulin belongs to a kind of active immunity, in the body to produce tetanus toxin, can also achieve the therapeutic purpose. Patients who are at risk of tetanus infection should be injected with tetanus-related reagents as soon as possible, and a strict sensitivity test is required before administering tetanus to avoid life-threatening allergic reactions.