Patients with delayed infection after thoracolumbar spine surgery are often due to the presence of immunocompromised, contaminated wounds or severe systemic infections. Patients should return to the orthopedic department or related surgical department as soon as possible, and cooperate with the doctor to take measures such as braking and resting, applying anti-infective drugs, and secondary surgery. 1. Braking and resting: after the onset of the disease, these patients should adopt the supine position and stay in bed to prevent the relevant parts from being squeezed and stimulated, which may lead to aggravation of infection or pathological fracture. 2. Application of anti-infective drugs: some sensitive anti-infective drugs should be applied to this kind of patients. For example, at this time, you can carry out bacterial culture on the secretion of the lesion area, and then choose sensitive antibiotics to carry out treatment according to the culture results. Commonly used are cephalosporin antibiotics, such as ceftriaxone sodium, cefotaxime sodium and so on. 3. Secondary surgical treatment: For some patients with particularly severe lesions, another surgery is needed. At this time, it may be necessary to remove the relevant internal fixation devices, and remove the necrotic tissue and place drainage devices. After surgery, anti-infective treatment should be continued. It is recommended that patients seek medical attention and follow the doctor’s instructions, rather than using medication blindly.