Dry and flaky leg skin can be caused by lack of sebaceous glands, dry skin, age and weather factors, etc. It can be treated with topical dimethicone, vitamin E and allantoin according to the cause. 1. Lack of sebaceous glands: It is recommended to use dimethyl silicone oil, which can repair the sebaceous membrane damaged due to the decrease of sebum secretion, thus forming a water-locking barrier on the skin. 2. Dry skin: Vitamin E can be taken under the guidance of a doctor, which can have the functions of antioxidant, skin moisturizing and repairing the skin barrier. 3. Age and weather factors: Topical allantoin can enhance the skin’s moisturizing ability, which can allow the skin to absorb water. And it forms a lubricating film on the surface of the skin to avoid water loss, which helps repair dry skin. In addition, the diet should eat more carrots, nuts, animal offal and other foods rich in vitamins A, B, E, and high-quality protein such as lean meat. It may also be caused by other diseases, and patients are advised to seek timely medical attention and follow the doctor’s instructions.