Bile reflux may be caused by pyloric relaxation, cholecystitis, gallstones and so on. 1. Pyloric relaxation: It is caused by gastrointestinal dysfunction, long-term poor dietary habits, etc. It will lead to acid reflux, heartburn, epigastric pain, bile reflux and other symptoms. 2. Cholecystitis: it is the inflammation of gallbladder caused by gallbladder stones, infection, ischemia of gallbladder, obstruction of bile discharge and so on, which is mainly characterized by pain and discomfort in the right upper abdomen, nausea, vomiting, bile reflux and other symptoms. 3. Gallstones: It is a disease in which stones occur in any part of the gallbladder and bile ducts due to a combination of environmental factors, genetic factors and personal lifestyle, manifesting as recurrent pain in the upper right abdomen, nausea, vomiting, bile reflux and other discomforts. Bile reflux may also be seen in gastric dysfunction, gastritis, and other disorders. If symptoms of bile reflux persist without relief, prompt medical attention is needed.