Running knee and ankle pain may be caused by not warming up, inappropriate shoes, excessive exercise and other factors, but there are differences between the causes of knee pain and ankle pain. 1. Knee pain: ① patellar tendonitis: if the patient suffers from long-term high-intensity exercise, it may cause inflammation of the patellar tendon, and the pain is aggravated when running or jumping. ② meniscus injury: if the patient running posture is not correct, too much strength, easy to cause meniscus injury, running pain. ③ Osteoarthritis: if the patient’s knee has osteophytes, it will cause osteoarthritis, resulting in pain when running. 2. Ankle pain: ①Trauma: If the patient’s foot has old fall, impact and other factors caused by trauma has not healed, then running will cause ankle pain symptoms. ② tenosynovitis: if the patient in a period of time in the ankle area too much activity, may cause tenosynovitis, running will cause pain. Ankle Strain: Inappropriate running posture and ill-fitting shoes can lead to ankle strain and cause pain. There are many other factors that can cause knee pain and ankle pain when running, and patients should go to the hospital in time for examination and diagnosis.