Down screening mostly refers to the Down’s syndrome screening, Down screening abnormalities include critical risk, high-risk risk, need to be based on the severity of the abnormalities and abnormalities of the program, to develop the next step in the treatment program, generally divided into continuing pregnancy, termination of pregnancy two programs. 1. Critical risk: If the result of the test is a critical risk phenomenon for trisomy 21 or trisomy 18, it is recommended to carry out further non-invasive DNA testing. If there is no abnormality, the pregnancy can be continued. For those with abnormality, amniocentesis is recommended to clarify whether there is any chromosomal abnormality, and those with abnormality need to consider termination of pregnancy. 2. High risk: If Down’s syndrome screening shows that trisomy 21 and trisomy 18 are high risk, chromosomal examination is needed to determine whether there are chromosomal abnormalities, and those with chromosomal abnormalities need to consider termination of pregnancy. 3. Neural tube defects as high risk: If the results of the Down’s syndrome screening suggest that there is a high risk of neural tube abnormalities, it is recommended that ultrasonography be performed to determine whether the fetal neural tube has developed abnormally. If the test result shows no obvious abnormality, the pregnancy can be continued with regular checkups, but termination of pregnancy should be considered for those who show the presence of neural tube developmental abnormality in the fetus. In the case of Down’s syndrome, it is recommended that a doctor’s visit be combined with other relevant tests to comprehensively determine the condition of the fetus, and then follow the doctor’s instructions for symptomatic treatment.