Taking statin lipid-lowering drugs should pay attention to the adverse reactions, contraindications, precautions and interactions with other drugs. 1. Adverse reactions: mainly myalgia, hepatic impairment, gastrointestinal reactions, skin flushing, headache, etc., but also may appear rhabdomyolysis aminotransferase elevation and other more serious side effects. 2. Contraindications: hypersensitivity to drug components, pregnant and lactating women, active liver disease, patients with unexplained persistent elevation of aminotransferases are prohibited. 3. Precautions: During the use of the drug, when acute allergic symptoms, such as laryngeal edema, dyspnea, etc.; symptoms of liver damage, such as jaundice, abdominal discomfort, deepening of the color of the urine, etc.; symptoms of muscle damage, such as unexplained muscle pain, tenderness, weakness, immediately stop using the drug and go to the hospital for medical attention. 4. Drug interactions: cyclosporine, gemfibrozil, tipranavir, ritonavir, telaprevir, etc. can lead to increased risk of statin myopathy and rhabdomyolysis, prohibit the use of combined drugs with statins. Statins as a common clinical lipid-regulating drugs, must be used under the guidance of a specialist physician, strictly grasp the contraindications, the emergence of adverse reactions to the hospital in a timely manner.