The initial symptoms of a positive nucleic acid test for novel coronavirus are atypical and consist mainly of symptoms of upper respiratory tract infection, such as nasal congestion, runny nose, sneezing, and malaise. Early symptoms of pneumonia in novel coronavirus infection are not specific. For patients with mild disease, only low-grade fever and malaise are manifested, with no signs of pneumonia, and there are no significant abnormal changes on early chest radiographs. In patients with severe pneumonia of novel coronavirus infection, dyspnea or hypoxemia can be seen in the early stage, and severe patients can show difficult to correct metabolic acidosis, acute respiratory distress syndrome, septic shock, disseminated intravascular coagulation, etc. In severe patients, lung function decreases rapidly, and thus there is obvious respiratory distress. During the period of novel coronavirus infection, it is necessary to closely monitor whether there are symptoms such as fever, cough, fatigue, etc., and take good personal protection to minimize the occurrence of infection. Tip: The terms “neocoronavirus pneumonia and neocoronavirus pneumonia” mentioned in this article were renamed to “neocoronavirus infection” on December 26, 2022, as announced by the National Health Commission.