Severe pain in the kidney area may be caused by pyelonephritis, perinephric abscess or kidney stone, etc. General treatment, medication or surgery can be taken according to the cause. 1. Pyelonephritis: in the acute stage, pain in the kidney area may occur, and it is accompanied by abdominal pain, generalized soreness, blood in urine and other symptoms. Quinolones such as levofloxacin and ciprofloxacin should be given as soon as possible after the diagnosis is confirmed, and the medication should be adjusted according to the result of drug sensitivity. 2. Perinephric abscess: Perinephric abscess is easy to cause pain in the kidney area, and it will affect normal urination, which is related to infection factors. Ciprofloxacin, levofloxacin and other drugs should be used as soon as possible for anti-infection treatment; if there is urethral obstruction, surgery is needed as soon as possible to relieve the obstruction. 3. Kidney stones: Kidney stones may also cause severe pain in the kidney area. If the stone is relatively small, you can use tamsulosin to remove the stone. If the stone is large, then consider doing extracorporeal shock wave lithotripsy, percutaneous nephrolithotripsy treatment. The causes of severe pain in the kidney area are many and the condition is more complicated, before treatment, we need to distinguish the cause of the disease, reasonable use of medication, we recommend that patients go to the hospital in time, under the guidance of a professional physician standardized treatment.