Atypical membranous nephropathy occurs most often between the ages of 30 and 50, with nephrotic syndrome as the main clinical manifestation, such as proteinuria, hypoproteinemia, edema, hyperlipidemia, and possibly hematuria. Common complications such as renal vein thromboembolism. Atypical membranous nephropathy has a relatively high incidence of microscopic hematuria compared with patients with atopic membranous nephropathy; and it has lower blood albumin, as well as higher quantitative 24-hour urinary protein; it can be combined with hyperlipidemia due to the increased production of lipids and decreased metabolism; and hypo-proteinemia makes plasma colloid osmolality decrease, and water enters into the interstitial space of the tissues, resulting in edema. Due to hyperlipidemia and old age, patients are prone to complications of renal vein thromboembolism, which manifests itself as a sudden onset of severe low back pain and worsening of hematuria and proteinuria. Atypical membranous nephropathy is mainly characterized by multiple deposits of immunoglobulins and complement, and diffuse proliferation of stromal and mesangial cells, while patients with atypical membranous nephropathy do not have proliferation. Patients with atypical membranous nephropathy are advised to go to regular hospitals for diagnosis, clarification of the cause of the disease, and standardized treatment according to the doctor’s instructions.