The clinical symptoms of mitral regurgitation are related to the severity of the condition and cannot be generalized into a top ten list of symptoms. Mitral regurgitation consists of two types: acute and chronic, and the clinical symptoms are related to the severity of the disease. When acute mitral regurgitation occurs, the patient’s left atrial pressure rises within a short period of time, causing shortness of breath and even dyspnea. When chronic mitral regurgitation occurs, clinical symptoms are related to the degree of mitral valve insufficiency. If the mitral valve is mildly closed, when the mitral valve is slightly regurgitated, the patient may not have any symptoms, or just a decrease in activity endurance, palpitations, chest tightness, wheezing, and a feeling of fatigue and weakness after overexertion. However, if the mitral valve is severely closed insufficiency, such as the mitral valve has a cleft, at this time the mitral valve regurgitation is obvious. The patient will have lower limb edema, nocturnal paroxysmal dyspnea or even telangiectasia, acute pulmonary edema, etc., which often causes left heart failure. Mild mitral regurgitation can be followed up regularly for observation and active treatment of various disease factors affecting the function of the mitral valve; for moderate-to-severe mitral regurgitation, mitral valve repair or replacement surgery should be performed as soon as possible to avoid the development of a significantly enlarged heart and a state of cardiac failure.