For patients with indications, spironolactone and furosemide can be taken for a long time, and blood pressure and electrolytes should be regularly rechecked in the course of drug taking. Spironolactone belongs to the commonly used diuretics, indications are hypertension, heart failure, diuretic at the same time with the role of potassium preservation, furosemide diuretic at the same time with the role of potassium excretion, the two at the same time in combination, the diuretic effect will be significantly increased, but the side effects will offset each other, patients with heart failure can be taken for a long time, the main indications include edematous disorders, heart failure, hypertension, hyperkalemia and so on. Adverse effects of spironolactone include gynecomastia, breast swelling and pain, hyperkalemia, etc. It is contraindicated for patients who are allergic to the drug components and hyperkalemia. Adverse reactions of furosemide include weakness, tinnitus, dizziness, nausea, electrolyte disorders, etc. It is contraindicated for patients who are allergic to the drug components. It is recommended to use it under the supervision of a physician, as well as to monitor electrolyte levels.