A high fever of 39 degrees with cold hands and feet may be caused by upper respiratory tract infection, encephalitis, enteritis and other diseases. 1. Upper respiratory tract infection: 39 degrees Celsius will be accompanied by cold limbs, which is due to the primary stage of the body, when the body temperature has not yet reached the peak, the symptoms of cold hands and feet will appear. 2. Encephalitis: viral encephalitis can cause cold hands and feet, fever and other symptoms, thus causing poor peripheral circulation. After viral infection, the toxins in the body will lead to increased body temperature but cold hands and feet. 2. enteritis: because the stomach and intestines are infected by bacteria, viruses or other pathogenic bacteria can lead to an acute attack of gastroenteritis, which can lead to fever, chills all over the body and cold limbs. If the symptoms of cold hands and feet with a high fever of 39 degrees persist, it is recommended to go to a regular medical institution in time to avoid delaying the condition.