Rheumatoid arthritis with nephrotic syndrome (nephrotic syndrome), including the treatment of drugs (such as penicillamine, meloxicam, etc.) caused by secondary nephrotic syndrome and primary nephrotic syndrome, if secondary nephrotic syndrome, we recommend first stop using the relevant drugs, to observe the condition, generally stop using the drugs, nephrotic syndrome can be relieved; if primary nephrotic syndrome, generally available hormone therapy. Rheumatoid arthritis is a chronic systemic connective tissue disease, due to rheumatoid arthritis caused by renal blood flow abnormalities or ischemia, abnormal immune response and other pathological changes, or the use of penicillamine, non-steroidal anti-inflammatory drugs (eg, ibuprofen, meloxicam, etc.), which may lead to renal syndrome. For drug-induced renal syndrome, need to stop the drug in time, close observation, generally after stopping the relevant drugs, renal syndrome can be relieved, if the symptoms continue to be unrelieved, hormone therapy can be used. For primary renal syndrome caused by rheumatoid arthritis, it can be treated with hormone therapy, such as prednisone, dexamethasone, etc., and at the same time, it can be combined with the use of methotrexate and other immunosuppressant treatments for treatment. In the use of hormone therapy, if secondary diabetes, gastrointestinal ulcers and other adverse reactions need to consult a doctor in time. The use of hormones is prohibited in cases of drug allergy. For pregnancy and lactation, hypertension, peptic ulcer, mental abnormality, glaucoma and other conditions usually do not recommend the use of special circumstances need to be rigorously assessed and used with caution. The above drugs need to be used under the supervision of a clinician. Patients with rheumatoid arthritis and nephrotic syndrome are advised to go to regular hospitals for timely consultation.