Dry flaky skin on the thighs may be caused by dry weather and improper washing and care, which can be corrected by applying topical moisturizers and correcting poor washing and care practices. However, it may also be caused by ichthyosis, dry eczema and other diseases, should be based on different causes using different drugs to improve. 1. Physiological factors: if it is due to dry weather, excessive scalding and other reasons, you can apply local vitamin E milk and other emollients, and adjust the appropriate water temperature for bathing, which is conducive to relieving the symptoms of dry and flaky skin. 2. Ichthyosis: a keratinization disorder characterized by dry skin with ichthyosis-like scales. Usually the main external drugs, such as urea cream, calcipotriol ointment, etc., can play a moisturizing, improve the role of keratinization. In severe cases, oral medication such as Avitamin A can also be taken to relieve the condition. 3. Dry eczema: dry, cracked skin with flaking as the main manifestation, may be accompanied by itching. Patients can use white petroleum jelly, mineral oil and other emollients, itching is serious, under the guidance of the doctor oral loratadine, cetirizine and other drugs. At the same time, it is also necessary to avoid the use of irritating lotions, so as not to aggravate the condition. Thigh skin dry flakes, the patient should consult a doctor in a timely manner, a clear diagnosis, and targeted treatment, the specific use of drugs need to follow the doctor’s instructions.