Non-invasive DNA can be used to check for chromosomal abnormalities in the fetus, but it is not necessary to do 100 items for pregnancy screening to be good. Non-invasive DNA is a more accurate test than Down’s screening, and further non-invasive DNA or amniocentesis can be done when there is a high or critical risk of Down’s screening. The non-invasive DNA 100-item test is more comprehensive and is done during pregnancy to rule out chromosomal abnormalities. It can screen for trisomy 18-trisomy, trisomy 21-trisomy, and trisomy 13-trisomy and these three findings will fulfill the need for screening. In addition, if you are of advanced maternal age or have other risk factors, amniocentesis is recommended, although there are some risks and a higher accuracy rate. If the non-invasive DNA screening result is still high risk, further amniocentesis is needed to confirm the diagnosis. Just pay more attention to rest during pregnancy, follow the doctor’s instructions to do the labor and delivery checkups on time, and observe all aspects of the fetus.