Ankylosing spondylitis patients taking diclofenac sodium treatment after the effect is not good may be insufficient dosage, the progress of the disease and other factors, can be adjusted by adjusting the drug regimen or increase the dosage of diclofenac sodium to improve. 1. Adjust the drug regimen: diclofenac sodium belongs to non-steroidal anti-inflammatory drugs, if ankylosing spondylitis patients oral diclofenac is not good, can be replaced with another non-steroidal anti-inflammatory drugs such as celecoxib, etoricoxib and other non-steroidal anti-inflammatory drugs, and if necessary, you can also consider the use of biologics, such as adalimumab and other therapies. 2. Increase the dosage: If ankylosing spondylitis is not well treated with diclofenac and the dosage of diclofenac has not yet reached the highest single-day dose, then the dosage of diclofenac sodium can be increased appropriately in order to enhance the effect of anti-inflammatory and pain relief. Diclofenac sodium should be used under the guidance of a physician, it is recommended that patients go to the rheumatology and immunology department of a regular hospital for detailed consultation, do not increase or decrease the dose of the drug.