The usefulness of removing submandibular gland for squamous carcinoma of the tongue cannot be generalized due to different individual circumstances. In most patients, if there is no contraindication to surgery, removal of the submandibular gland as prescribed by the doctor is generally useful. Most cancers of the tongue are squamous cell carcinomas, which are highly differentiated in terms of differentiation. Once diagnosed with squamous cell carcinoma of tongue, if the patient’s disease stage is early, his condition is relatively not serious, and there is no metastasis, the majority of patients can have a good prognosis by removing the submandibular gland, which can control the development of the disease, as well as prolong the survival time and improve the quality of life. However, due to the different conditions of individuals, some patients have already entered the middle and late stages of the disease when they are diagnosed, and if they have lymph node metastasis, even if they undergo the surgery of removing the submandibular gland, the therapeutic efficacy will be poorer. Therefore, if patients with squamous carcinoma of tongue want to undergo surgery to remove submandibular gland, they need to take into account their own conditions and ask their doctors for guidance. After the surgery, they should follow the doctor’s instruction to have regular checkups in order to know the recovery of the disease.