CD36 is a multifunctional transmembrane glycoprotein for metabolic and cardiovascular diseases. CD36 mediates cellular uptake of oxidized low-density lipoprotein (ox-LDL), induces the transformation of monocytes into foam cells, and promotes atherosclerosis formation through inflammatory responses, oxidative stress, platelet activation, and macrophage capture. The severity of atherosclerosis could be significantly alleviated by inhibiting the expression of CD36 or interfering with its related signaling pathway. In addition, high expression of CD36 in the tongue, nasal cavity, small intestine, and brain promotes the body’s lipid uptake and absorption and increases disease risk factors for metabolic diseases. Serum soluble CD36 is a component of circulating particles and may be a predictor of cardiovascular disease. For more medical expertise, please refer to the relevant literature or consult your doctor.