Taking antihypertensive drugs hand swelling may be due to the adverse reaction of antihypertensive drugs, may also be due to trauma, rheumatoid arthritis, malnutrition and other diseases. 1. Adverse reaction of antihypertensive drugs: taking some kind of drugs with increased vascular permeability, such as amlodipine, nifedipine, etc., will cause edema, and at this time, you can change the drug or change the dosage of antihypertensive drugs under the guidance of the doctor. 2. Trauma: Soft tissue injury due to trauma can cause swelling of the upper limbs. 3. Rheumatoid arthritis: there will be synovitis changes in the joints of the hands, such as swelling of the wrist joints, metacarpophalangeal joints, pain, and morning stiffness. 4. Malnutrition: due to malnutrition, the body’s albumin decreases, osmotic pressure increases, there will be swelling of the hands and even the whole body. Hand swelling is not necessarily caused by antihypertensive drugs, it is recommended that patients go to the hospital in a timely manner to clarify the cause of the disease, to be targeted treatment.