The unevenness of the glans after unclean sex can be considered to be caused by sexually transmitted diseases such as condyloma acuminatum, or it can be related to diseases such as penile perlage and glansitis. 1. Condyloma acuminatum: Condyloma acuminatum is related to human papillomavirus infection, which is a sexually transmitted disease and can be induced by unclean sex. 2. Penile Pearl Rash: Penile Pearl Rash can be related to factors such as physiological developmental variations and local stimuli, long foreskin, poor local hygiene and cleanliness can increase the risk of the disease. Mainly manifested in the coronal groove and glans and other parts of the translucent, pearly rash of pimples, can be light red, yellow and white, etc., there may be local uneven performance. 3. Glans: Infectious factors, non-infectious factors, allergies, autoimmune skin diseases and other reasons can cause glans, local mucosal edema, erythema, erosion and ulceration, etc., skin lesions can appear uneven performance. The above symptoms may also be caused by other factors, it is recommended that patients go to the regular hospital in time for treatment, and strive for early recovery.