Itching of the limbs at night may be a skin disease such as pruritus, urticaria or frostbite. It can be dealt with by oral antihistamine medication, topical frostbite cream, and warm water compresses. 1. Pruritus. Manifested as itchy skin without obvious skin lesions. The symptoms can be relieved by antihistamines, commonly used drugs are chlorpheniramine maleate, cyproheptadine, loratadine and so on. 2. Urticaria. Manifested as erythema of the skin with itching. You can take oral antihistamines, such as diclofenac tadine, ebastine or levocetirizine. 3. Frostbite. Easy to develop in the cold season, manifested as red, swollen, itchy hands and feet, partly accompanied by pain. Frostbite cream can be used externally and warm water can be applied to relieve the symptoms. The drugs mentioned above need to be used under the guidance of a doctor, and the itching of the limbs at night can go to the dermatology department. Drugs should be used under the guidance of a doctor.