If there is no serious and intolerable adverse reaction after taking the quadruple drug for a week, it is recommended to follow the course of treatment and not to change the drug arbitrarily. Quadruple drug refers to 1 proton pump inhibitor + 2 antibiotics + 1 bismuth agent, for the current clinically advocated eradication of Helicobacter pylori treatment of the combined program, the general course of treatment for 10 to 14 days. At present, you have been taking the quadruple combination of drugs for one week, and changing the drugs at this time will lead to the risk of failure of H. pylori eradication and susceptibility to relapse, so it is recommended that you continue to take the drugs under the guidance of your doctor. If there are serious gastrointestinal reactions, headaches, allergies and other intolerable adverse reactions during the course of taking the quadruple combination of drugs, you can switch to other drugs for bactericidal treatment as prescribed by your doctor. If the adverse reactions are mild or the symptoms improve during the course of the medication, it is recommended to continue taking the original regimen. The medication program is the doctor in accordance with the patient’s specific situation to make targeted treatment program, it is recommended to follow the doctor’s instructions to take medication to avoid adverse effects.