Lymph node enlargement of 15mm is recurrent and unexplained, puncture biopsy can be performed. Lymph node aspiration biopsy is suitable for patients with recurrent lymph node enlargement. Lymph node aspiration biopsy is mainly used to remove part of the diseased tissue through puncture for examination, so as to determine the cause of lymph node enlargement. Patients with recurrent unexplained lymph node enlargement of 15mm can be punctured to determine the cause of the disease and clarify the treatment plan. After lymph node puncture, patients should pay attention to local hygiene to avoid infection, which may aggravate the condition of enlarged lymph nodes, and should maintain good work and rest habits and dietary habits in daily life, avoid staying up too late to stimulate the intake of food, and at the same time, avoid excessive stress, and actively treat. Lymph node enlargement 15mm should promptly identify the cause of treatment.