Valsartan and amlodipine extended-release tablets have different drug components, different mechanisms of action, different adverse reactions and contraindications. 1. Different drug components: the main component of valsartan is valsartan, and the main component of amlodipine extended-release tablets is amlodipine. 2. Different mechanisms of action: the main mechanism of valsartan is to inhibit the angiotensin II receptor, which can reduce the generation of angiotensin in the body, and the main component of amlodipine is to inhibit the calcium ion in-flow, and there is a significant difference between the two mechanisms of action. 3. Adverse reactions and contraindications are different: valsartan’s adverse reactions are flu-like symptoms, nasal congestion, nausea, vomiting, creatinine elevation, etc., allergic to the drug components, severe renal insufficiency, breastfeeding and pregnancy women are prohibited. Adverse reactions to amlodipine include lower extremity edema, reactive tachycardia, dry stools, etc. It is contraindicated in patients who are allergic to the components of the drug. Both drugs need to be taken under the guidance of a professional physician, and should not be used without authorization.