Breast ultrasound should focus on the presence of breast nodules as well as nodule description and classification, calcifications, and special signs for a comprehensive interpretation. Mammography is the most commonly used breast imaging test with high sensitivity to both breast tissue and lumps. The characterization of breast masses is a very important part of the study. Most benign and malignant breast diseases manifest as masses, i.e., breast nodules. The shape, margins, and echogenicity of the nodules are relevant to the assessment of the benignity or malignancy of the mass, e.g., irregularities, unclear margins, and hypoechoicity are signs of suspected malignancy. According to the assessment of the risk of malignancy, the lumps can be divided into 0~6 categories. 0 category is a single examination, which can not clearly determine that there is a breast nodule, and it needs to be determined by other examinations, while generally 1~3 categories are more likely to be benign, and can be followed up on a regular basis, 4~5 categories have a certain risk of malignancy, and need to be performed by a puncture biopsy, and 6 categories are diagnosed malignant by histological examination. Coarser calcifications are typically benign, while smaller, irregular, clustered calcifications may be malignant. Specialized signs such as blood supply, skin condition, and structural distortions are helpful in the initial diagnosis of the lesion. The ultrasound report needs to be analyzed by combining multiple descriptions, and other imaging studies such as mammograms need to be read together if available. It is recommended that the patient consult a specialist for the report and follow the doctor’s instructions for further examination and analysis.