If HPV16 is found to be positive in cervical cancer screening, whether it is serious or not requires further colposcopy, and if necessary, it needs to be combined with cervical biopsy and sent for pathology examination in order to make it clear. HPV16 is a high-risk virus, and its positivity is closely related to the occurrence of cervical cancer, if not actively treated, the risk of cervical lesions and cervical cancer will be significantly higher. For HPV16 positive patients, it is recommended to further improve the colposcopy examination, if necessary, cervical biopsy to send the pathology examination to clarify the type of cervical lesions, if only chronic cervicitis or low-grade lesions, you can follow the doctor’s instructions to use drugs such as interferon treatment, generally not serious. If it is a high-grade lesion, it needs to be treated by LEEP or cold knife conization surgery; if it is cervical cancer, it needs to be treated by surgery, and may need to be treated with radiotherapy after the surgery. This is a more serious case. For women who are found to be positive for HPV type 16, they should pay attention to it and are advised to go to the gynecology department of a regular hospital for active treatment under the guidance of the doctor, so as to avoid further development of the disease.