Calf pressure pain may be caused by excessive exercise, acute injury, vascular lesions and other factors. 1. Excessive exercise: exercise for a long time, may lead to the accumulation of lactic acid metabolites in the muscles of the calf area, when pressed, there will be pain, mainly manifested as soreness, the pain is not strong, and can be relieved by itself after reasonable rest. 2. Acute injury: for example, muscle strain or external blow, resulting in local muscle damage, which will cause pain when pressing, and may also be accompanied by swelling, subcutaneous bruising. 3. Vascular lesions: for example, varicose veins or phlebitis, which may lead to pathological reactions such as insufficient blood supply or poor blood reflux, and will cause pain when pressed. Painful pressure on the calf and other discomforts that last for a long time are recommended to seek medical examination as well as treatment to avoid adverse effects.