Myelofibrosis is a malignant disease of the hematologic system. In myelofibrosis grade 1, sometimes there are no obvious clinical symptoms, sometimes it shows mild anemia and thrombosis, and there may be white blood cells and persistent thrombocytosis in laboratory tests. Treatment includes observation and monitoring, targeted treatment, etc. 1. Some people without clinical symptoms can continue to monitor the changes of indicators regularly for several years without special treatment. 2. When symptoms appear, such as anemia, androgen therapy, such as danazol, etc.; increased platelet count, hydroxyurea, interferon therapy, etc. can be chosen. If the diagnosis of myelofibrosis grade 1, it is recommended to go to the hospital in time, under the guidance of the doctor for standardized treatment, the above drugs should not be taken on their own.