Knee tenderness can be treated with rest, physical therapy, medication, and surgery if it is caused by a knee pathology. If it is caused by trauma, it can be treated with rest and medication. 1. Knee soreness and tenderness can be treated by rest, wearing knee pads to protect the knee, and physical therapy such as hot compresses and massage of the knee if it is caused by arthritis, such as osteoarthritis, rheumatoid arthritis, and so on. (1) Oral anti-inflammatory and analgesic drugs, such as nimesulide and diclofenac sodium, can also be taken for treatment. (2) Sodium vitrate can also be injected into the joint cavity to improve the symptoms. (3) If the joint damage is serious, it can also be treated by surgery, such as arthroscopic joint cleaning or artificial knee replacement. 2. If the weakness is caused by traumatic injury to the knee joint, it is necessary to pay attention to proper rest, oral anti-inflammatory and analgesic medication and external fixation with plaster casts or braces to promote recovery. 3. If the leg weakness is caused by compression of nerves by lumbar disc herniation or spinal stenosis, it can be treated by wearing a lumbar immobilizing belt and physiotherapy such as hot compresses, baking electricity and tuina. (1) Anti-inflammatory and analgesic drugs as well as neurotrophic drugs such as methylcobalamin adenosylcobalamin can also be taken orally. (2) If the nerve compression is serious and conservative treatment is ineffective, you can also choose surgical treatment, such as decompression of the spinal canal, bone grafting and internal fixation. 4. If knee weakness is caused by excessive activity, it can be improved by resting and applying localized heat. If the symptoms of knee weakness occur, it is recommended that the patient go to the hospital to clarify the cause of the disease and receive regular treatment. The use of the above drugs should be in accordance with medical advice.