Vertebral compression fracture with bone marrow edema is serious enough. Vertebral compression fractures are due to pathologic fractures caused by spinal trauma or bone tumors, and bone marrow edema occurs as a result of localized edema oozing after the fracture. After the fracture occurs, there will be obvious pain and limitation of activities. Minor fractures require bed rest for 8 weeks and avoidance of floor activities. If the compression fracture is more than 1/3 or combined with spinal nerve injury is more serious, surgical treatment, vertebroplasty is needed. If the compression fracture caused by bone tumor needs to perform tumor removal vertebral nail rod fixation. Therefore, vertebral compression fracture with bone marrow edema is more serious need to go to the hospital spine surgery for further treatment.