The treatment of interosseous leiomyoma should depend on your own situation, mainly related to the size of the leiomyoma, if it is small, it can be treated with medication and regular follow-up observation, if the leiomyoma is large, it needs to be treated with surgery. The treatment of interosseous leiomyosarcoma depends on the size of the tumor, as follows: 1. Follow-up observation: if the size of leiomyosarcoma is small, asymptomatic or without other complications, or if the patient is close to menopause, the level of estrogen will be greatly reduced after menopause, and the leiomyosarcoma may shrink or disappear. As long as the patient has regular checkups and observes the changes of the fibroid, the fibroid may shrink or disappear. 2. Medication: If the leiomyoma causes abdominal pain, heavy menstruation and affects pregnancy, medication can be taken. Common drugs include gonadotropin-releasing hormone agonists such as leuprolide and goserelin, progesterone antagonists such as mifepristone, etc. If accompanied by uterine bleeding, you can take antiemetic drugs, such as tranexamic acid. 3. Surgery: If the fibroid is large and even has the possibility of malignant transformation, it should be treated by surgery in time. Such as myomectomy, hysterectomy and so on. The treatment of myofibroblastoma should be combined with one’s own situation, and it is recommended to go to the hospital in time and choose the suitable treatment plan under the doctor’s guidance. All of the above drugs should be used under the guidance of a doctor to avoid causing adverse reactions.