Sertraline and Duloxetine are not recommended to be taken together, Sertraline and Duloxetine both belong to the antidepressant drugs, the two side effects are more, taken together as a duplication of medication, and prone to adverse reactions. It is recommended to choose the right drug under the guidance of a professional doctor. Sertraline side effects can be seen in loss of appetite, nausea, diarrhea, constipation, dyspepsia, palpitations, drowsiness, excessive sweating, tremor, dizziness, insomnia, dry mouth, sexual dysfunction and other symptoms; allergic to the product and the ingredients contained in this product, patients with manic depression, patients with severe hepatic and renal insufficiency, patients with the use of monoamine oxidase inhibitors, such as moclobemide, Seregiline, patients with the use of sertraline is prohibited. Duloxetine side effects may manifest as dizziness, nausea, headache, fatigue, drowsiness, dry mouth, lightheadedness and constipation. Or duloxetine is contraindicated in patients with severe renal impairment. Sertraline and Duloxetine taken together will increase the danger of side effects, antidepressant patients need to take the drug under the guidance of a doctor, do not take without authorization, to avoid adverse reactions, take the drug during the period of time, please avoid drinking alcohol or drinks containing alcohol.