Sebaceous gland hyperplasia may be caused by androgen stimulation, trauma and localized chronic inflammatory stimulation, and long-term immunosuppressive treatment. 1. Androgens: In newborns, androgen stimulation can lead to an increase in the number of fetal sebaceous glands and an increase in the size of sebaceous gland goblet cells, resulting in an increase in sebaceous glands. 2. Trauma and local chronic inflammatory stimulation: Animal experiments show that local contact with chemicals such as croton oil, neosporin, citral, and long-term ultraviolet irradiation can induce sebaceous gland hyperplasia in hairless mice. 3. Long-term immunosuppressive treatment: some studies show that 16% of organ transplant patients who receive immunosuppressive treatment, especially long-term treatment, have this disease. If you suffer from sebaceous gland hyperplasia, it is recommended to go to a regular hospital to clarify the cause of the disease and standardize the treatment under the guidance of the doctor.