The chances of being fine with a high-risk Down’s syndrome test are not clinically defined. Down’s syndrome screening is a common mid-trimester serologic screening method, and the optimal time for testing is between 16 and 18 weeks of pregnancy. When the results of the test indicate a critical risk, non-invasive DNA testing is recommended. When the test results indicate a high risk, amniocentesis is recommended for a definitive diagnosis. Down’s syndrome screening is only a screening tool, not a definitive diagnosis. Down’s syndrome screening is not suitable for all pregnant women, for example, for suspected fetal malformations, one of the spouses has a genetic disease, pregnant women older than 35 years old, should be under the guidance of the obstetrician to choose the appropriate screening method. Pregnant women should pay attention to the prenatal examination during pregnancy, actively listen to the advice of professional doctors to do a comprehensive nursing care, pay attention to rest, at the same time, should relax, avoid tension, anxiety, any discomfort should be timely to the hospital, the doctor to clarify the diagnosis, and cooperate with the doctor to deal with the symptoms.