Vacuolated cells in squamous epithelium refers to abnormal squamous cells with more vacuoles in the cytoplasm of normal squamous epithelium, which is commonly seen after human papilloma virus (HPV) infection. Human squamous epithelium within the squamous cells by the human papilloma virus (HPV) infection, the damaged cells to accelerate the differentiation and maturation, the formation of abnormal squamous cells, this cell cytoplasm can be seen in the cytoplasm of a number of vacuoles of varying sizes, so it is known as the vacuolar cells, also known as dugout cells. The microscopic manifestation of vacuolated cells seen within the squamous epithelium is generally used clinically to diagnose atypical hyperplasia of the squamous epithelium and other low-grade lesions, which are mostly clinically benign, and are generally commonly seen in diseases such as condyloma acuminatum.