Severe hair loss due to clogged scalp follicles is considered to be caused by folliculitis, ringworm of the scalp, seborrheic alopecia, and so on. It should be treated according to the cause. 1. Folliculitis: bacterial infection of scalp follicles can cause inflammation of the follicles and their surrounding tissues, resulting in severe hair loss. Patients can use topical erythromycin ointment, fusidic acid cream, etc. under the guidance of the doctor, or oral amoxicillin, cefadroxil and other sensitive antibiotics to fight infection. 2. Tinea capitis: it is caused by dermatophyte infection, which can also lead to scalp follicle inflammation and severe hair loss. Patients need to cut the hair as much as possible, topical ketoconazole lotion, miconazole cream and other antifungal drugs, while following the doctor’s instructions oral itraconazole, terbinafine and other antifungal drugs. 3. Seborrheic alopecia: it is a kind of non-scarring alopecia, which is manifested by the miniaturization of hair follicles and progressive atrophy of hair follicles, and the phenomenon of serious hair loss. Patients with seborrheic alopecia can use topical minoxidil and so on, at the same time, male patients can follow the doctor’s instructions to take a small oral dose of finasteride, female patients can take oral spironolactone and other medications; in addition, patients with the need for hair transplantation, according to their own actual situation and the physician’s advice to choose hair transplantation treatment. Scalp follicle clogging hair loss may also be caused by other diseases, it is recommended that patients go to the regular hospital in time for examination, a clear diagnosis of standardized treatment in accordance with the doctor’s instructions.