Red and swollen pimples that don’t budge and don’t go away are mostly considered to be caused by folliculitis, boils, nodular acne and other diseases, which need to be treated with medication, physical therapy and surgery for the specific disease. 1. Folliculitis: mainly caused by bacterial infection, can be treated with topical antibiotics, such as mupirocin ointment, fusidic acid cream, etc.; the effect of topical treatment is not good, but also with oral antibiotic treatment, such as erythromycin, doxycycline and so on. 2. Boils: related to bacterial infection, can be treated with topical antibiotics, such as mupirocin ointment, gentamycin hydrochloride ointment, etc.; when the local drug treatment is ineffective, oral antimicrobials can be used, such as penicillin, ceftriaxone sodium, etc.; infrared rays, lasers, and other physical treatments can be taken to eliminate the boils; surgical incision and drainage is needed if necessary. 3. Nodular acne: topical antibiotic treatment, such as fusidic acid cream, etc.; when the area is large, oral isotretinoin treatment, but there are teratogenic side effects, pregnant women and women of childbearing age is prohibited; if necessary, can be taken to the red and blue light and other physical therapy. It is recommended that patients go to the dermatology department of regular hospitals to clarify the cause and follow the doctor’s instructions for treatment, not blindly self-medication to avoid causing adverse reactions.