Domestic inactivated vaccines are relatively good, but there are also advantages and disadvantages, as described below. 1. Inactivated vaccine: the advantages of the domestic inactivated vaccine are generally higher safety, and the production of the vaccine is faster, the production process is also more mature. The disadvantage of inactivated vaccine is that the vaccination dose is large, and the number of times of vaccination will be more, the antibody in the body to maintain the time will be relatively short. 2. Anhui Zhifei Recombinant New Crown Vaccine: The advantage of Anhui Zhifei Recombinant New Crown Vaccine is that it can be mass-produced and is highly safe. The disadvantage is that the choice of expression system will affect the antigenicity, so the choice of expression system will be limited. 3. New crown adenovirus vector vaccine: The advantage of new crown adenovirus vector vaccine is that it has higher safety and better effect, and clinical investigation found that fewer groups have adverse reactions to this vaccine. The disadvantage of the neocoronavirus vector vaccine is that the effectiveness of the vaccine is affected by pre-existing immunity, which needs to be taken into consideration during the development and production of the vaccine. According to the current study, the domestic vaccine is still effective in preventing the new coronavirus after injection, and active vaccination is recommended.