Typically, the prognosis for gastrointestinal mesenchymal tumors is generally favorable, but there may be a small number of patients with a relatively poor prognosis. Gastrointestinal mesenchymal tumors are common mesenchymal-derived tumors of the GI tract and account for the majority of GI mesenchymal tumors. When they first occur, gastrointestinal mesenchymal tumors are usually benign, but as they slowly evolve, they may lead to the development of malignancy. Patients suffering from gastrointestinal mesenchymal tumors can be treated in regular hospitals through surgery or targeted therapy to remove the tumor or design appropriate therapeutic drugs for the cancer-causing areas that have been clearly identified. Most of the patients can get the tumor under control through resection surgery or targeted therapy, and the prognosis is often good. However, if a patient with gastrointestinal mesenchymal stromal tumor is malignant, with the spread of cancer cells, the prognosis may be relatively poor after surgical treatment or targeted therapy. If patients suffer from gastrointestinal mesenchymal tumor, they should seek medical treatment in time and standardize the treatment under the guidance of professional doctors to avoid delaying the condition.