For vitiligo, no matter which part of the body is usually more difficult to treat, perianal vitiligo is also the same, but the site is relatively hidden, the impact on the patient’s life treatment is smaller, but will still cause a certain degree of psychological pressure on the patient. Vitiligo is due to the destruction of skin melanocytes, resulting in the skin due to the lack of melanin and the appearance of pigment loss skin disease, can occur in any part of the body, mainly manifested in the skin mucous membranes of the loss of pigmentation patches, the patient’s appearance and the quality of life have a certain impact. The disease is chronic, and some patients may get better on their own, or alternately get better and worse. There are also some patients whose lesions do not develop for a long time and are fixed in a certain part of the body, i.e., stable vitiligo, individual patients will have a tendency to heal on their own, and there are also some patients whose white spots will develop further. Whether it is vitiligo in the perianal area or other parts of the body, it is more difficult to treat, but it is also necessary to actively cooperate with the doctor’s treatment, it is possible to improve the appearance of the skin, or even restore the skin color, and control the increase and expansion of the white spots.