Redness, swelling and hard lumps around the eye of the needle after vaccination may be a normal reaction to vaccination, or it may be caused by an allergic reaction or localized infection. It needs to be treated according to the specific situation. 1. Normal reaction to vaccination: local stimulation of muscle or soft tissue caused by vaccination, an inflammatory reaction manifestation. 24 hours can be used to reduce the redness and swelling of ice cold compresses, more than 48 hours after the hot towel can be used to apply hot compresses, to promote blood circulation, reduce the symptoms. 2. Allergic reaction: the body is allergic to some components of the vaccine may appear redness, swelling, hard lumps and even itching and other symptoms. You can apply local glycerin lotion to stop itching or take oral loratadine to reduce the allergic reaction. 3. Localized infection: redness, swelling, hard lumps, even pain, local fever and other conditions may occur when the needle eye is infected by bacteria after vaccination. Topical antibiotic ointment such as mupirocin cream can be used for antibacterial treatment. After the vaccine appeared some abnormalities, it is recommended to consult a doctor in time, do not blindly self-medication treatment.