Dipyridamole and sartan antihypertensive drugs can be used in combination, but you need to pay attention to adjusting the drug regimen, as well as pay attention to adverse reactions and contraindications. The essence of diphenhydramine antihypertensive drugs is non-dihydropyridine calcium channel blockers, which can inhibit myocardial contraction, reduce myocardial oxygen consumption, diastolic peripheral resistance vessels, and improve the symptoms of hypertension; sartans antihypertensive drugs are essentially angiotensin Ⅱ blocking agents, which can reduce vascular tenseness and inhibit water reabsorption to reduce blood pressure. The two mechanisms are different and no contraindications can be combined. If a combination of drugs is needed, the clinician should make a comprehensive assessment of the condition and then adjust the original dosage and method of use. If adverse reactions such as skin rash or diarrhea occur during administration, it is recommended to stop using the drug and consult a physician. Allergy, hypotension, etc. are prohibited; hepatic and renal insufficiency, pregnancy and lactation need to be careful with the use of the drug. The above drugs should be used under the supervision of a clinician.