Rosiglitazone belongs to the thiazolidinediones class of hypoglycemic drugs, belongs to the insulin sensitizer, clinically at present is mainly used for the control of type 2 diabetes mellitus, can be applied with other drugs. Rosiglitazone efficacy and function: on the basis of diet and exercise control, for other drugs poor control of type 2 diabetes mellitus people’s blood sugar control. Rosiglitazone may cause mild edema, hypoglycemia, anemia, and liver function abnormalities during administration. Rosiglitazone should be used with caution in children, the elderly, pregnant women, and patients with edema; it is contraindicated in people with a history or high risk of heart failure, people with heart disease, people with severe lipid metabolism disorders, and people who are allergic to the product. Rosiglitazone should be monitored for changes in blood glucose, blood lipids, and liver and kidney functions; contraception should be observed during the period of use; do not drink alcohol during the period of use; and once there are obvious abnormalities in cardiac function, body edema, abnormalities in liver and kidney functions, and generalized skin rashes during the period of use, it is necessary to discontinue the use of the medication and consult a doctor for observation in a timely manner, so as to avoid delays in medical conditions. Rosiglitazone needs to be used under the guidance of a doctor, avoiding self-medication.