Wake up at 4 o’clock every morning may be physiological reasons, there may be mental reasons, there may be symptoms of certain diseases, such as gastrointestinal diseases, prostate hyperplasia, etc., you should consult a doctor to find out the cause of the disease. 1. Physiological reasons: may be with age, the body function gradually decline, it is difficult to maintain enough sleep time, resulting in patients with shorter sleep at night, easy to wake up early; and often night shifts biological clock disorders, irregular life may also appear every morning at 4:00 am waking up the situation. 2. Mental reasons: the patient may be living and working under pressure, excessive depression, anxiety, tension, sadness and other emotions, resulting in poor quality of sleep at night, sleep is not stable, and early waking will also occur. 3. Gastrointestinal diseases: Early waking patients may suffer from gastrointestinal diseases, such as indigestion, gastric ulcer, etc., there is excessive secretion of gastric acid at night, the patient may have acid reflux, belching, etc., appearing to wake up at 4:00 in the morning. 4. prostate hyperplasia: some men may suffer from prostate hyperplasia, resulting in frequent urination at night, frequent urination in the toilet, will also have an impact on sleep, resulting in waking up at 4:00 in the morning. It should be noted that if physiological reasons are excluded, you should go to the hospital in time, ask the doctor to clarify the cause of the disease, and if necessary, carry out appropriate treatment.